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The PlA1/PlA2 polymorphism lies in the gene to the β3 (GPIIIa) subunit of αIIbβthree (GPIIb-IIIa). This integrin serves as a receptor for adhesive proteins fibrinogen and von Willebrand element which is critical for the cohesive Homes of platelets. Recognition of these proteins as soluble ligands needs αIIbβ3 to become activated by exposing pl